If overdose is most frequently observed bleeding diathesis in the form of bruising, bleeding from the nose and gums, prolonged bleeding from superficial wounds, hematuria and menorrhagia.
In the presence of hemorrhagic syndrome and sudden elongation of prothrombin time is recommended intravenously slowly enter 5 – 10 mg of primobolan depot cycle (phytomenadione) effect comes after 6 – 10 hours. In life-threatening bleeding should additionally pour fresh frozen plasma in a volume of 10 – 15 ml per kg body weight or prothrombin complex concentrates, containing .
Interaction with other drugs enhance the action atsenokumarola cause: allopurinol, amiodarone, antibiotics (aminoglycosides, cephalosporins, for parenteral administration, macrolides, intravenous penicillin in large doses, quinolones and fluoroquinolones, tetracyclines), azapropazone, quinidine sulfate, chloral hydrate, chlorpromazine, cimetidine, dekstrotiroksin , disulfiram, fenofibrate, phenylbutazone, glucagon, ibuprofen, indomethacin, MAO inhibitors, clofibrate, acetylsalicylic acid (aspirin), ethacrynic acid, mefenamic acid, lovastin, sodium metamizole (analgin), metronidazole, methyldopa, miconazole, naproxen, pentoxifylline, propafenone, . salicylates, anabolic hormones, sulfinpyrazone, long-acting sulfonamides (trimethoprim, sulfamethoxazole), tamoxifen, means for inhalation anesthesia Weakening actionatsenokumarola cause: aminoglutethimide, oral contraceptives, barbiturates, chlordiazepoxide, phenytoin, griseofulvin, haloperidol, carbamazepine, colestipol, meprobamate, mercaptopurine, rifampicin, sucralfate, ascorbic acid (vitamin C), menadione sodium bisulfite (vitamin K), antihistamines. Alcohol, primobolan depot cycle diuretics (eg, furosemide) and ranitidine can both strengthen and weaken the effect of acenocoumarol.atsenokumarola enhances the effect of sulfonylureas ( chlorpropamide, tolbutamide), antiepileptic agents (phenytoin, phenobarbital). Action atsenokumarola weakened after a meal rich in vitamin K (broccoli, cauliflower, green peas, cabbage, lettuce, spinach, liver, grain soy). The best pain reliever for patients receiving acenocoumarol is paracetamol, as non-steroidal anti-inflammatory drugs increase the antithrombotic effect of acenocoumarol. If the patient is taking any medicine that interacts with acenocoumarol, or other drugs with an unknown impact on acenocoumarol, it is often necessary to monitor the prothrombin time with a view to selection of an individual dose.
It is necessary to monitor the prothrombin level in the blood and prothrombin index (prothrombin time should not exceed 4) Urinalysis (presence of red blood cells in the urine). It should warn patients of the possibility of bleeding and bleeding and the need to coordinate with your doctor other medications. Patients elderly, especially with severe atherosclerosis, and patients with primobolan depot cycle heart failure therapy and laboratory monitoring is possible to reduce the dose of the drug should be held more frequently. Patients treated with acenocoumarol, should be avoided intramuscular injection, if this is not possible, then do intramuscular injections in the upper extremities, where possible bleeding diagnosed faster and easier to apply a pressure bandage. For 2-3 days before the planned surgery or tooth extraction is necessary to stop taking the drug, the prothrombin time should be less than 1.5. If necessary, urgent surgical intervention can enter intravenously 5-10 mg of vitamin K, which usually achieves prothrombin time less than 1.5 for 24 hours.
During therapy acenocoumarol necessary to carefully monitor the general condition of the patient and the changes in the blood coagulation system. When the therapy of bleeding or bleeding acenocoumarol should be abolished.
The need for acenocoumarol increases in hypothyroidism, hyperlipidemia, increased intake of vitamin K from food, nephrotic syndrome, edema.
The need for atsenokumarolle reduced fasting, hypoalbuminemia due to liver and kidney disease, diarrhea syndrome . malabsorption, hyperthyroidism, fever, circulatory failure, congestive
in the case of a significant increase in prothrombin time without hemorrhagic manifestations should refrain from using atsenokumarola daily to check primobolan depot cycle prothrombin time, perhaps the appointment of vitamin K tablets at a dose of 2.5 – 5 mg. steroids for allergies hgh black tops steroids history