methenolone enanthate side effects

At the beginning of therapy Sinkardom possible transient increase in the level of “liver” enzymes.
Before starting therapy and then regularly liver function tests (to monitor the activity of “liver” enzymes every 6 weeks during the first 3 months, then every 8 weeks for the remainder of the first year and then one every six months) and at higher doses of the test should be conducted to determine liver functions. By increasing the dose to 80 mg of the test should be carried out every 3 months. When persistent elevations of enzyme activity (3-fold compared with baseline) reception Sinkarda should be discontinued.
Sinkard, like other inhibitors of methenolone enanthate side effects reductase inhibitors, should not be applied at an elevated risk of rhabdomyolysis and renal failure (on the background of severe acute infection, hypotension, planned major surgery, trauma, severe metabolic disorders).
Cancel lipid-lowering drugs during pregnancy has no significant impact on the long-term treatment of primary hypercholesterolemia.
Application Sinkarda not recommended for women of childbearing potential not using contraception.
patients with reduced thyroid function (hypothyroidism), or in the presence of certain diseases of the kidneys (nephrotic syndrome), with an increase in cholesterol levels should first carry out treatment of the underlying disease.
Sinkard with caution appoint persons who abuse alcohol and / or have a history of liver disease.
Prior to and during treatment the patient should be on hypolipidemic diet.
Co-administration of grapefruit juice may enhance the severity of side effects associated with taking Sinkarda, so avoid their simultaneous reception.
Sinkard not granted in cases of hypertriglyceridemia.
treatment with simvastatin may cause myopathy, methenolone enanthate side effects¬†leading to rhabdomyolysis and renal failure. The risk of this disease increases in patients receiving simultaneously with simvastatin one or more of the following drugs: fibrates (gemfibrozil, fenofibrate), cyclosporine, nefazadon, macrolides (erythromycin, clarithromycin), antifungal agents of “azole” group (ketoconazole, itraconazole) and ¬†protease inhibitors (ritonavir). The risk of myopathy is also increased in patients with severe renal insufficiency.
All patients who start therapy with simvastatin and patients who need to increase the dose of the drug should be warned of the possibility of myopathy and need immediate treatment to the doctor in case of unexplained pain, pain in muscle flaccidity or muscle weakness, particularly if accompanied by malaise or fever. Drug therapy should be discontinued immediately if myopathy is diagnosed or suspected.
In order to diagnose myopathy is recommended to conduct regular measurements .
In the treatment with simvastatin may increase the content of serum , which should be considered in the differential diagnosis of chest pain. Drug withdrawal criterion is an increase in serum methenolone enanthate side effects more than 10 times the upper limit of normal. Patients with myalgia, myasthenia and / or marked increase in drug treatment is stopped.
The drug is effective as a monotherapy, or in combination with bile acid sequestrants.
Patients with severe renal insufficiency treatment is carried out under the control of renal function.
The duration of the drug is determined by the attending the doctor individually.
Effects on ability to drive and use machines
on the adverse effects of simvastatin on the ability to drive and work with the mechanisms have not been reported.

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