primobolan depot

Butamirata, the active ingredient of the drug Sinekod is central antitussive action, not chemically or pharmacologically related to the opium alkaloids. Has primobolan depot expectorant, mild bronchodilatory and anti-inflammatory effect, it has a direct effect on the cough center, improves spirometry (reduces airway resistance) and blood oxygenation.

Butamirata rapidly and completely absorbed by ingestion. After receiving 150 mg butamirata maximum plasma concentration of the main metabolite (2-phenylbutyric acid) is achieved in about 1.5 hours and is 6.4 ug / ml. The half-life of 6 hours. With the reappointment of the drug concentration in the blood remains linear and accumulation was observed. Hydrolysis butamirata initially to 2-phenylbutyric acid and dietilaminoetoksietanola starts in blood. These metabolites also possess antitussive activity. Like butamirata metabolites have nearly maximum (about 95%) degree of binding to plasma proteins, which leads to, among other things, their prolonged plasma half-life. Metabolites are excreted mainly in the urine, the metabolites acidic largely linked to glucuronic acid.

Indications

Dry cough from any primobolan depot cause (including whooping cough). The suppression of cough in the pre- and postoperative period after surgery and bronchoscopy.

Contraindications
: Hypersensitivity to the drug, children under 3 years of age (for children up to 3 years old can apply Sinekod drops for oral administration).

Use during pregnancy and lactation

In studies conducted in animals, there were no adverse effects on the fetus. Controlled studies in pregnant women have been conducted. Therefore Sinekod should not be used in I trimester of pregnancy. In II and III trimester use Sinekoda possible taking into account the benefits for the mother and the potential risk for ploda.Uchityvaya lack of data on the release of the active substance with the breast milk, Sinekoda appointment during lactation is not recommended.

Dosing and Administration
Inside, the food.
Children from 3 to 6 years old – 5 ml 3 times a day,
6-12 years – 10 ml three times a day for
12 years and older – 15 ml 3 times a day;
adults -. 15 ml 4 times a day,
use a measuring cap (attached).

Side effects are
skin rash, nausea, diarrhea, dizziness (frequency less than 1%), and allergic reactions.

Overdosing Symptoms: primobolan depot drowsiness, nausea, vomiting, diarrhea, loss of sense of balance and blood pressure.

Treatment: activated carbon, saline laxatives, maintain the function of the cardiovascular and respiratory systems.

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