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Maximum plasma concentration achieved after 3 hours after dosing. Since plasma protein binds to 98%, In the body of the drug. The half-life of approximately 8-9 hours. Atsenokumarola primobolan depot bayer metabolized in the liver. Approximately 60% of the drug released to the body is excreted in the urine, mainly in the form of metabolites remaining amount excreted in the feces. The degree of elongation of prothrombin time or increase prothrombin index is independent of the concentration in blood acenocoumarol.

Indications for use.
Thrombosis, thrombophlebitis, thromboembolic complications of myocardial infarction, embolism of various organs (prevention and treatment). In surgical practice for the prevention of thromboembolic complications in the postoperative period.

Contraindications.
Haemorrhagic diathesis and other diseases accompanied by reduced blood clotting, kidney failure, marked disturbances of liver function, hypertension, cancer, diabetic retinopathy, physical exhaustion, hypoprothrombinemia (less than 70%), hypovitaminosis , bleeding from open wounds, gastric ulcer and duodenal ulcer, ulcerative colitis, hemorrhagic stroke (first 2 months), pregnancy, lactation, threatening miscarriage, postpartum eclampsia and pre-eclampsia, chronic endocarditis, pericarditis, dissecting aortic aneurysm, immediately after surgery in ophthalmology, neurology and primobolan depot bayer dentistry after lumbar puncture biopsies of organs or aortic puncture for 4 days.

Dosage and administration.
The drug is used inside. The dose is determined individually, depending on the parameters of blood clotting. On the first day, the dose is 6 – 8 mg per day, followed by 4 mg per day under the control of the prothrombin time, which should be in the range of 2.0 – 3.5 seconds. Reception frequency – once daily at one and the same time.

Side effects.
Nausea, diarrhea, alopecia, headache, allergic reactions such as skin rash and angioedema bleeding, skin hemorrhages, and mucous membranes (in the degree of reduction of the frequency of occurrence): hematuria, bleeding from the gums, petechiae, traumatic hematoma, melena, metrorrhagia, hemarthrosis, a hemorrhagic stroke. Very rarely can develop a syndrome of purple feet and necrosis of the skin and subcutaneous tissue. The cause of the purple feet syndrome are probably primobolan depot bayer microthrombuses cholesterol. This complication appears after several weeks of treatment and appears bluish hyperpigmentation feet and big toes, and pain in the big toes. Hyperpigmentation disappears when pressing and lifting the limb. Skin necrosis initially takes the form of erythema or rash papular pyatnisto- that appears on the chest, thighs and buttocks, may also be in the upper extremities, face and genitals. In the case of the first skin necrosis symptoms should immediately remove the drug and prescribe vitamin K or heparin, which may prevent the development of complete necrosis.
Withdrawal – increase the risk of thrombosis. steroiden kaufen

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